bzip transcription factor human

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DNA-binding domain Wikipedia There are three retinoic acid receptors (RAR), RAR-alpha, RAR-beta, and RAR-gamma, encoded by the RARA, RARB, RARG genes, respectively. Orthologous to human CEBPB (CCAAT enhancer binding protein beta). CREB1 Gene - GeneCards | CREB1 Protein | CREB1 Antibody This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. estrogen receptor 1 Zinc finger JUN (Jun Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. It is primarily STAT1 See also. A pseudogene of this gene is found on chromosome 1. It can also form heterodimers with the related protein CEBP-alpha. CCAAT/enhancer binding protein bZIP transcription factor, bZIP_1; Suggested Antigen Peptide Sequences for BACH1 Gene FLJ94404, Homo sapiens BTB and CNC homology 1, basic leucine zippertranscription factor 1 (BACH1), mRNA (Q6ICU0_HUMAN) Transcription factor BACH1t (Q9BXM4_HUMAN) Graphical View of Domain Structure for InterPro Entry O14867. Pregnane X receptor 20682 Ensembl ENSG00000125398 ENSMUSG00000000567 UniProt P48436 Q04887 RefSeq (mRNA) NM_000346 NM_011448 RefSeq (protein) NP_000337 NP_035578 Location (UCSC) Chr 17: 72.12 72.13 Mb Chr 11: 112.67 112.68 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor SOX-9 is a protein that in humans is encoded by the Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 that is encoded by the HIF1A gene. AP-1 transcription factor A typical bZIP domain consists of a leucine zipper region, and a basic region. Transcription factor 2002; 76:1281312822. CEBPD Gene - GeneCards | CEBPD Protein | CEBPD Antibody The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which Diseases associated with CREB1 include Histiocytoma, Angiomatoid Fibrous and Melanoma Of Soft Tissue.Among its related pathways are MyD88 dependent cascade initiated on endosome and RNA Polymerase I Promoter Opening.Gene Ontology (GO) annotations related to this gene 165030 TFs with at least one binding motif (4559 from direct experiments), out of a total of 392333 TFs from 321 families in 741 species A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions (Zn 2+) in order to stabilize the fold.It was originally coined to describe the finger-like appearance of a hypothesized structure from the African clawed frog (Xenopus laevis) transcription factor IIIA.However, it has been found to encompass a wide variety of differing TCF7L2 Function. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. Human T-cell leukemia virus type 1 (HTLV-1) is the causal agent of a neoplastic disease of CD4 + T cells, adult T-cell leukemia Devaux C, et al. Estrogen receptor Sp1 transcription factor c-Rel has an important role in B-cell This protocol describes DAP-seq, a transcription-factor binding site discovery assay that can be used to produce cistrome and epicistrome maps for any organism. AP-1 transcription factor is assembled through the dimerization of a characteristic bZIP domain (basic region leucine zipper) in the Fos and Jun subunits. As a member of the TCF family, TCF7L2 can form a bipartite transcription factor and influence several biological Diseases associated with JUN include Sarcoma and Teratocarcinoma.Among its related pathways are Hepatocyte growth factor receptor signaling and MyD88 dependent cascade initiated on endosome.Gene Ontology (GO) annotations related to this gene include RNA Diseases associated with ATF4 include Coffin-Lowry Syndrome and Fatty Liver Disease.Among its related pathways are NFAT and Cardiac Hypertrophy and Glucose / Energy Metabolism.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and FOSL2 c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor.It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the JUN gene. Gene. Retinoid X receptor FOSL2 (FOS Like 2, AP-1 Transcription Factor Subunit) is a Protein Coding gene. PAX5 FOS The c-Rel protein is a member of the NF-B family of transcription factors and contains a Rel homology domain at its N-terminus and two C-terminal transactivation domains. bZIP Factor Gene ID: 4780, updated on 9-Oct-2022. J Virol. Basic leucine zipper (bZIP) proteins, which belong to an evolutionarily conserved transcription factor family and play critical roles in various biological processes in eukaryotes, have been previously identified in U. virens; however, their PXR belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand FOS (Fos Proto-Oncogene, AP-1 Transcription Factor Subunit) is a Protein Coding gene. The function of TFs is to regulateturn on and offgenes in order to make sure that they are expressed in the desired cells at the right time and in the Estrogen receptors (ERs) are a group of proteins found inside cells.They are receptors that are activated by the hormone estrogen (17-estradiol). bZIP transcription factor transcription factor The coding sequence contains five regions showing a high degree of conservation in vertebrates, predominantly in exons 2, 5, 6, 7 and 8, but the sequences found in invertebrates show only c-Jun overexpression in CAR T cells induces exhaustion resistance Some DNA-binding domains may also include nucleic acids in their folded structure. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Binding of agonist ligands to RXR results in dissociation of corepressor and recruitment of coactivator protein, which, in turn, promotes transcription of the downstream target gene into mRNA and eventually protein. 20683 Ensembl ENSG00000185591 ENSMUSG00000001280 UniProt P08047 O89090 RefSeq (mRNA) NM_001251825 NM_003109 NM_138473 NM_013672 RefSeq (protein) NP_001238754 NP_003100 NP_612482 NP_038700 Location (UCSC) Chr 12: 53.38 53.42 Mb Chr 15: 102.31 102.34 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor Transcription factor Jun is a protein that in humans is encoded by the JUN gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, according to preliminary FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling, and is also central to the decision for a preadipocyte to commit to adipogenesis. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer. SOX9 PXR is a nuclear receptor whose primary function is to sense the presence of foreign toxic substances and in response up regulate the expression of proteins involved in the detoxification and clearance of these substances from the body. Diseases associated with IRF4 include Skin/Hair/Eye Pigmentation, Variation In, 8 and Whipple Disease.Among its related pathways are Dendritic Cells Developmental Lineage Pathway and IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types. The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. HIF1A c-jun was the first oncogenic transcription factor discovered. NFE2L2 Nuclear factor NF-IL6-beta (CEBPD_HUMAN) Graphical View of Domain Structure for InterPro Entry P49716. IRF4 FOSL1 Gene - GeneCards | FOSL1 Protein | FOSL1 Antibody Retinoic acid receptor; Retinoid X receptor alpha; Retinoid X receptor beta; Retinoid X receptor gamma; References CREB1 (CAMP Responsive Element Binding Protein 1) is a Protein Coding gene. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the paired box.The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. MAFB (MAF BZIP Transcription Factor B) is a Protein Coding gene. Diseases associated with FOSL2 include Breast Cancer.Among its related pathways are IL-1 Family Signaling Pathways and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics.Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor Wikipedia MAFB Gene - GeneCards | MAFB Protein | MAFB Antibody The proto-oncogene c-Jun JUN Multiple transcript variants encoding different isoforms Current content: 11491 motifs. Hepatocyte nuclear factor 4 alpha Diseases associated with FOSL1 include Colorectal Cancer and Trichorhinophalangeal Syndrome, Type I.Among its related pathways are IL27-mediated signaling events and IL-1 Family Signaling Pathways.Gene Ontology (GO) annotations related to this gene include DNA-binding This gene is located within the SmithMagenis syndrome region on chromosome 17. Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. Transcription factor 7-like 2 (T-cell specific, HMG-box), also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. FOSL1 (FOS Like 1, AP-1 Transcription Factor Subunit) is a Protein Coding gene. In humans, the TP53 gene is located on the short arm of chromosome 17 (17p13.1). Summary. 20846 Ensembl ENSG00000115415 ENSMUSG00000026104 UniProt P42224 P42225 RefSeq (mRNA) NM_007315 NM_139266 NM_001205313 NM_001205314 NM_009283 NM_001357627 RefSeq (protein) NP_009330 NP_644671 n/a Location (UCSC) Chr 2: 190.91 191.02 Mb Chr 1: 52.16 52.2 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Signal Rice false smut, caused by Ustilaginoidea virens, is one of the most destructive diseases in major world rice-producing regions. The PAX5 gene is a member of the paired box (PAX) family of transcription factors. This gene encodes an estrogen receptor and ligand-activated transcription factor. The gene spans 20 kb, with a non-coding exon 1 and a very long first intron of 10 kb. Diseases associated with FOS include Congenital Generalized Lipodystrophy and Osteoblastoma.Among its related pathways are MyD88 dependent cascade initiated on endosome and IL27-mediated signaling events.Gene Ontology (GO) annotations related to this Mapping genome-wide transcription-factor binding The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF.. HIF1A is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional regulator Retinoic acid receptor IRF4 (Interferon Regulatory Factor 4) is a Protein Coding gene. ATF4 The p-TEFb complex containing this cyclin was reported to interact with, and act as a negative regulator of human immunodeficiency virus type 1 (HIV-1) Tat protein. ENCODE Transcription Factor Targets BACH1 The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. ATF4 is a pivotal transcription factor that mediates not only ER stress, we performed a yeast 2-hybrid screen using the ATF4 bZIP domain as bait and screened against a cDNA library. ATF4 (Activating Transcription Factor 4) is a Protein Coding gene. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes.This gene plays a role in development of the liver, kidney, and intestines. Exhaustion was associated with a profound defect in the production of IL-2, along with increased chromatin accessibility of AP-1 transcription factor motifs and overexpression of the bZIP and IRF transcription factors that have been implicated in mediating dysfunction in exhausted T cells 7-10. Diseases associated with MAFB include Multicentric Carpotarsal Osteolysis Syndrome and Duane Retraction Syndrome 3 With Or Without Deafness.Among its related pathways are Tacrolimus/Cyclosporine Pathway, Pharmacodynamics and Nervous system development. Used to study cleidocranial dysplasia and viral infectious disease. Two classes of ER exist: nuclear estrogen receptors (ER and ER), which are members of the nuclear receptor family of intracellular receptors, and membrane estrogen receptors (mERs) (GPER (GPR30), ER-X, and G q-mER), Sterol regulatory element-binding protein CIS-BP Database: Catalog of Inferred Sequence Binding Preferences The TCF7L2 gene is located on chromosome 10q25.2q25.3, contains 19 exons. [provided by Alliance of Genome Resources, Apr 2022] C/EBPbeta is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease. Transcription factor transcription factor The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid. Function. Wikipedia A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded DNA.A DBD can recognize a specific DNA sequence (a recognition sequence) or have a general affinity to DNA. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen Function. Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. 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